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发明公开
CN109956959A 一种7-苯乙酰氨基去乙酰氧基头孢G酸及其制备方法 无效 - 驳回

一种7-苯乙酰氨基去乙酰氧基头孢G酸及其制备方法
摘要：
本发明提供了一种7‑苯乙酰氨基去乙酰氧基头孢G酸及其制备方法，其是将所述7‑苯乙酰氨基去乙酰氧基头孢G酸溶液和所述酸溶液通入超重力反应器中进行反应，控制液体出口的pH值在出晶点以上，即可制得7‑苯乙酰氨基去乙酰氧基头孢G酸晶体，所得晶体的粒径分布为：Dv（10）=80~90μm，Dv（50）=185~200μm，Dv（90）=360~380μm。本发明采用连续法生产7‑苯乙酰氨基去乙酰氧基头孢G酸晶体，解决了现有间歇制备工艺中存在的制备工时长、生产不连续、产品溶解性差等问题，在保证产品质量的同时，提高了产品收率，降低了生产成本，产品粒度更为均匀，晶体溶解速度快，产品适用性更广，增加了经济效益。
摘要（英）：

The invention provides 7-phenylacetamidodeacetoxycephalosporin G acid and preparation method thereof. The method comprises the following steps: introducing a 7-phenylacetylaminodeacetoxycephalosporinG acid solution and an acid solution into a supergravity reactor for reaction, and controlling the pH value of a liquid outlet to be higher than crystallization value to prepare the 7-phenylacetylaminodeacetoxycephalosporin G acid crystal. The particle size distribution of the crystal is as follows: Dv (10) = 80-90 [mu]m, Dv (50) = 185-200 [mu]m, and Dv (90) = 360-380 [mu]m. The 7-phenylacetamidodeacetoxycephalosporin G acid crystal is produced by the continuous method, so that the problems of long preparation time, discontinuous production, poor product solubility and the like in the existingintermittent preparation process are solved; according to the method, the product quality is ensured, the product yield is improved, and the production cost is reduced. The product is more uniform ingranularity, high in crystal dissolving speed and wider in product applicability, and economic benefits are increased.

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