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发明公开
CN109900907A 一种用于检测癌症抗原的纸基传感器元件及其制备方法 无效 - 驳回

一种用于检测癌症抗原的纸基传感器元件及其制备方法
摘要：
本发明公开了一种用于检测癌症抗原的纸基传感器元件及其制备方法，包括：滤纸纸基；羧基化碳纳米管，若干所述羧基化碳纳米管沉积于所述滤纸纸基，所述羧基化碳纳米管特征性结合有胰腺癌细胞的特异性抗体CA19-9。本发明能够将抗原浓度信息转换为直接可测的电信号，具有制造成本低，精度高，稳定性强的优点，可实现经济、快速的癌症抗原筛查；另外，本发明的传感器在低CA19-9浓度范围(0～40U/ml)下仍具有良好的探测性，在早期阶段能够发现胰腺癌。本发明传感器的检测时间只需两个小时左右，在检测效率上比ELISA快约12倍。
摘要（英）：

The invention discloses a paper-based sensor element for detecting cancer antigens and a preparation method of the paper-based sensor element. The paper-based sensor element comprises a filter paper base a carboxylated carbon nanotubes; the plurality of the carboxylated carbon nanotubes are deposited on the filter paper base; and the carboxylated carbon nanotubes are specifically bound with a specific CA19-9 antibody of pancreatic cancer cells. The paper-based sensor element of the invention can convert antigen concentration information into directly measurable electrical signals, has the advantages of low manufacturing cost, high precision and high stability, and can realize economical and rapid cancer antigen screening; the sensor of the invention has good detection performance under a low CA19-9 concentration range (from 0 to 40U/ml), can detect pancreatic cancer in an early stage; and the detection time of the sensor of the invention only takes about two hours, and the detection efficiency of the sensor is about 12 times higher than that of the ELISA (enzyme-linked immune sorbent assay).

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