The invention provides a simulation test evaluation system and method for a high-wear-resistance self-lubricating bionic sealing part, and relates to the technical field of high-wear-resistance self-lubricating bionic sealing parts. The system comprises a pressure-bearing part, a detection assembly, an execution assembly and a control assembly; the detection assembly is connected with the controlassembly; the execution assembly is connected with the control assembly; the execution assembly is connected with a test product containing a bionic sealing body; the control assembly controls the execution assembly to drive the bionic sealing body and the pressure-bearing part to carry out friction in a working solution; and the detection assembly is used for detecting multiple types of signals generated in friction contact and sending the signals to the control assembly so as to enable the control assembly to obtain the multiple types of signals. By simulating the friction process of the high-wear-resistance self-lubricating bionic sealing part of equipment under a real service condition, the technical problem that the friction damage of a sealing system of the equipment under an extremeenvironment condition is difficult to predict is solved, so that the technical effect of improving the service efficiency and reliability of the bionic sealing body in the friction process is achieved.