The invention discloses a reverberation inhibition processing method and device. The method includes: acquiring to-be-processed sound data which are first sound data containing reverberation; processing the first sound data according to a similarity matrix to obtain preliminary reverberation inhibited second sound data, wherein the similarity matrix is obtained by pre-training; processing the second sound data on the basis of a Wavenet network model which is obtained by pre-training; acquiring output third sound data from the Wavenet network model. By the reverberation inhibition processing method and the device, problems of low accuracy and application scene limitation of reverberation inhibition algorithms in the correlation technique are solved.