The invention discloses an anti-collision mechanism of a single-axis driver and the driver. The anti-collision mechanism comprises a platform body, a fixed block, sliding columns, a top block, a fixedpin shaft, a needle bearing, a photoelectric sensor and a detecting piece; the fixed block is slidably arranged on the outer side face of the platform body through the sliding columns, and the needlebearing is vertically arranged at the top of the fixed block; the rear end of the top block is inserted into a positioning hole in the outer side surface of the platform body, and the end surface ofthe front end abuts against an outer ring of the needle bearing; the sliding columns are arranged on the two sides of the top block, the rear ends of the sliding columns are screwed on the outer sidesurface of the platform body, and the front ends of the sliding columns slidably pass through the fixed block to be limited by lock nuts; the detecting piece is fixedly arranged on the fixed block, the photoelectric sensor is arranged on the platform body, the photoelectric sensor cooperates with the detecting piece, and therefore a motor of the single-axis driver shuts down when it is detected that the platform body and the fixed block generate relative sliding. The anti-collision mechanism is simple in structure, low in manufacturing cost and high in sensitivity during collision detecting, and mechanical equipment damage caused when collision happens can be effectively prevented.