The invention discloses a systemic lupus erythematosus detection reagent containing lncRNA and usage thereof. The lncRNA can regulate the expression of genes at various levels such as an epigenetic level, a transcription level, a post-transcriptional level, protein metabolism and the like, and the expression disorder is closely related to the occurrence and development of many human diseases. In order to discover novel molecular markers related to systemic lupus erythematosus, the reagent performs multi-center and multi-sample data integration analysis on existing high-throughput transcriptomesequencing data, and discovers the novel lncRNA and related genes, and the novel lncRNA provided for the systemic lupus erythematosus by the reagent has a good clinical application prospect.