The invention discloses an anti-corrosion and anti-blockage drainage pipe and a preparation method thereof. The anti-corrosion and anti-blockage drainage pipe drainage pipe comprises a plastic pipe, aself-cleaning layer and an anti-corrosion layer, wherein the anti-corrosion layer is uniformly sprayed on the inner wall of the plastic pipe, and the self-cleaning layer is uniformly sprayed on the surface of the anti-corrosion layer and comprises the following raw materials: nano-silver, glass powder, polystyrene and polydimethylsiloxane; the anti-corrosion layer comprises the following raw materials: polytetrafluoroethylene, carbon fiber, bisphenol A epoxy resin, additives, turpentine and a compatilizer. The pipe has the beneficial effects that a self-cleaning effect can be achieved, dirt in the pipe can be removed to achieve the effect of being in the silt but not imbrued, blockage of the drainage pipe is effectively prevented, and the pipe is provided with the anti-corrosion layer, sothat corrosion resistance and oxidation resistance of the pipe are increased, stability of the pipe is enhanced, and the service life of the pipe is prolonged.