The invention relates to the technical field of dustless paper packing, in particular to a full-automatic dustless paper packing folding machine. The machine comprises a first positioning frame, a second positioning frame, a dustless paper drum bearing device, an automatic loading and unloading device, an automatic shearing device and an automatic folding device; the dustless paper drum bearing device comprises a round roller bearing part, and two support parts arranged at two ends of the round roller bearing part; the round roller bearing part is erected on the first positioning frame; the automatic loading and unloading device comprises a first driving part, and a support part mounted at an output end of the first driving part; the automatic shearing device comprises a first roller partand a shearing part; the automatic folding device comprises a folding driving part and a folding bearing part; and an output end of the folding driving part is arranged towards the folding bearing part. The machine realizes the opposite folding operation of folded tissues; and through the operation mode of folding, cutting and opposite folding, the manpower output is reduced, and the working efficiency is improved.