The invention discloses a medical gypsum multi-stage pulverizing and grinding device. The device comprises a pulverizing and grinding device body and a pulverizing chamber, wherein a feeding port is arranged at the upper end of the pulverizing and grinding device body; a touch display is arranged at the surface at one side of pulverizing and grinding device body; a power button is arranged at thelower end of the touch display; a control box is arranged at the lower end of the power button; an exhaust fan starting rod is arranged on the surface of the control box; a pulverizing starting rod isarranged at one side of the exhaust fan starting rod; an access door is arranged at the lower end of the pulverizing starting rod; a first discharging port is arranged at the lower end of the other surface of the pulverizing and grinding device body; an exhaust opening is arranged at one side of the first discharging port; and a first rotating motor is arranged at the upper end of the exhaust opening. By arranging a main squeezing roller and an auxiliary squeezing roller, and through the relative movement between the main squeezing roller and the auxiliary squeezing roller, a larger gypsum ore is subjected to be pre-squeezed and crushed, and the efficiency of crushing is greatly improved.