The invention relates to an indirect type vacuum cooling crystallization system. The indirect type vacuum cooling crystallization system comprises a material liquid tank, a secondary steam condenser,a water storage tank, a compressor, a compressed steam condenser, a throttle valve, a vacuum pump, a circulating pump and a condensate tank. Low-temperature cold water is produced by a compressor in an air extraction flash evaporation mode, and indirect heat exchange is carried out on the low-temperature cold water and secondary steam in the material liquid tank, thereby maintaining continuous flash evaporation of a solvent in the material liquid tank, and achieving cooling crystallization of a material liquid. The indirect type vacuum cooling crystallization system has the advantages that when the system works, the secondary steam produced by the material liquid evaporation does not enter the compressor, and therefore, the corrosion of a compressor rotor by corrosive materials can be avoided; in addition, compared with a traditional steam-jet pump method cooling crystallization system, cooling load of the system is only the heat released by air extraction condensation and the heat converted during power consumption of the compressor, the use amount of cooling water is small, the cooling rate is quick, and the operation energy consumption is low.