The invention discloses a safe and intelligent dialysis device. The safe and intelligent dialysis device comprises a dialysis box, wherein the inner portion of the dialysis box is provided with a first dialysis bottle and a second dialysis bottle side by side, one side of the dialysis box is provided with a blood pump, the blood pump is in through connection with a blood transfusion tube arrangedin the dialysis box through a drainage tube, one end of the blood transfusion tube is in through connection with a first shunt tube and a second shunt tube in sequence, and the first shunt tube and the second shunt tube are in through connection with a first dialysis fiber pipe arranged in the first dialysis bottle and a second dialysis fiber pipe arranged in the second dialysis bottle respectively. The safe and intelligent dialysis device has the advantages that firstly, the first dialysis bottle and the second dialysis bottle are arranged, when a dialyzate of the first dialysis bottle needsto be replaced, the second dialysis bottle plays a dialysis role, the first dialysis bottle and the second dialysis bottle operate alternately so that uninterrupted long-time dialysis can be carried out on the blood, the trouble that the dialysis needs to be suspended when the dialyzate of a traditional dialysis device is replaced is avoided, the dialysis speed is increased, and the contaminationrisk caused by the replacement of the dialyzate is avoided.