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发明公开
CN109620828A 化疗后消化道不良反应的模型建立方法、模型和应用 无效 - 驳回

化疗后消化道不良反应的模型建立方法、模型和应用
摘要：
本发明提供了一种化疗后消化道不良反应的模型建立方法、模型和应用，涉及制药技术领域。该化疗后消化道不良反应的模型建立方法通过筛选化疗药物的给药剂量，然后按照筛选出的给药剂量对动物肿瘤模型进行化疗处理，获得化疗后消化道不良反应的模型；其中筛选化疗药物的给药剂量包括对经过化疗药物处理的动物肿瘤模型进行肠毒性评价，得到动物肿瘤模型出现消化道具有不良反应时的给药剂量。该方法得到的模型出现的消化道的不良症状是由化疗药物造成的，因此将该种模型用于研发缓解化疗后消化道不良反应的药物时，模型的症状更接近于实际的病理现象，有利于精准的筛选出药物和研究筛选出的药物的缓解化疗后消化道不良反应的机理。
摘要（英）：

The invention provides a modeling method for adverse reactions of the digestive tract after chemotherapy, a model and application, and relates to the technical field of pharmacy. The modeling method for the adverse reactions of the digestive tract after chemotherapy comprises the steps of screening the administration dosage of chemotherapy medicine, conducting chemotherapy treatment on an animal tumor model according to the screened administration dosage, and obtaining the model for the adverse reactions of the digestive tract after chemotherapy, wherein with the administration dosage of the screened chemotherapy medicine, enterotoxicity evaluation is carried out on the animal tumor model treated by the chemotherapy medicine, and the digestive tract of the animal tumor model has the adverse reactions. Bad symptoms of the digestive tract in the model obtained by means of the method are caused by the chemotherapy medicine, so that when the model is used for researching and developing medicine for relieving the adverse reactions of the digestive tract after chemotherapy, the symptoms of the model are closer to actual pathological phenomena, accurate screening of the medicine and researching on the mechanism of the screened medicine for relieving the adverse reactions of the digestive tract after chemotherapy are facilitated.

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