The present invention provides a foot-and-mouth disease virus-like particle vaccine and a preparation method therefor. The preparation method comprises: constructing a recombinant expression plasmid by inserting two ORFs of P12A and 3C genes of a codon-optimized FMDV in series into a transfer vector; or constructing a recombinant expression plasmid by cloning a single ORF containing the P12A3C gene into the vector under promoter SV40, transforming a competent cell to obtain recombinant Bacmid-DNA, transfecting sf9 cells, so as to obtain an insect cell capable of expressing foot-and-mouth disease virus-like granule proteins. After the cells have been cultured, the supernatant is collected, and the VLP is purified by means of ultrafiltration, centrifugation and chromatography to prepare a foot-and-mouth disease virus-like particle vaccine.