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发明公开
CN109563171A 结合PD-L1和LAG-3的结合分子 审中-实审 转让

结合PD-L1和LAG-3的结合分子
摘要：
本公开内容涉及结合程序性死亡蛋白配体1(PD-L1)和淋巴细胞活化基因3(LAG-3)的抗体分子。所述抗体分子优选包括针对PD-L1的基于CDR的抗原结合位点，以及位于所述抗体分子的CH3结构域的两个或更多个结构性环中的LAG-3抗原结合位点。本公开内容的抗体分子获得例如在癌症治疗中的应用。
摘要（英）：

The present disclosure relates to antibody molecules which bind to programmed death-ligand 1 (PD-L1) and lymphocyte-activation gene 3 (LAG-3). The antibody molecules preferably comprise a CDR-based antigen binding site for PD-L1, and a LAG-3 antigen binding site which may be located in two or more structural loops of a CH3 domain of the antibody molecule. The antibody molecules of the disclosure find application, for example, in cancer therapy.

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