The invention provides a vehicle unmanned driving active intervention system. The vehicle unmanned driving active intervention system comprises three monitors, a path monitoring device, a controller and an unmanned driving sub system; the first monitor is used for monitoring facial expression of a driver; the second monitor is used for monitoring the heart rate of the driver; the third monitor isused for monitoring the holding pressure of the driver to a steering wheel; the path monitoring device comprises a path processor; when there is no obstacle at the front end of a vehicle and a runningpath and a planned path have a difference, the path processor is used for judging and transmitting a path abnormal signal to the controller; when the controller judges any abnormal signal transmittedby the three monitors and receives path abnormality transmitted by the path processor, it shows that the physiological state or the psychological state of the driver is abnormal and the abnormality affects the operation of the vehicle; the controller controls the unmanned driving sub system to be started; and the unmanned driving sub system takes over the operation of the vehicle so as to enhancethe safety of the vehicle under an abnormal condition.