The invention discloses a method for preparing a Bi-2212 high-temperature superconducting wire. The method comprises the following steps: step one, carrying out tabulating of Bi-2212 powder to obtaina primary composite wire; step two, carrying out primary drawing on the primary composite wire to obtain a single-core wire; to be specific, carrying out annealing at a temperature of 250 DEG C to 280DEG C during primary drawing; step three, carrying out cutting, bundling, and tabulating on a single-core wire, carrying out secondary drawing to obtain a secondary composite wire, and repeating thesteps and carrying out third drawing to obtain a Bi-2212 wire; to be specific, carrying out annealing at a temperature of 250 DEG C to 280 DEG C during the secondary drawing and third drawing; and step four, carrying out semi-molten processing on the Bi-2212 wire to obtain a Bi-2212 high-temperature superconducting wire. According to the invention, the internal stress in the wire is eliminated bymeans of low-temperature annealing during drawing, so that mechanical property difference between the Bi-2212 powder and the silver sheath as well as the unevenness of the silver super-interface of the Bi-2212 wire is reduced, the grain ordering in the core wire is improved, and the current-carrying property of the Bi-2212 wire is enhanced.