The invention discloses efficient heat-transfer antipyretic patch. The efficient heat-transfer antipyretic patch is characterized by comprising a back lining layer, a gel layer and an isolation layer,the gel layer is arranged between the back lining layer and the isolating layer, the gel layer is composed of gel, modified porous graphene and antipyretic drug according to a mass ratio of 20:1-5:1-5. Modified graphene and hydrogel are mixed, the antipyretic drug is loaded, modified graphene has many holes, and loading space for the antipyretic drug can be provided; heat conductivity of modifiedgraphene is far better than high macromolecular hydrogel, so that higher heat transfer efficiency of the antipyretic patch generally is realized, action efficiency of the antipyretic drug is ensured,and antipyretic effect is improved.