The invention discloses an unlocking method, an unlocking device and unlocking equipment based on an intelligent lock and a medium. The method comprises the following steps: generating activating information and sending the activating information to a user terminal when an NFC module of the intelligent lock detects an unlocking signal and acquiring an unlocking request triggered by the user terminal based on the activating information; if an account number identifier in the unlocking request is matched with an intelligent lock identifier pre-stored in a database, generating a target random code and sending the same to the user terminal to obtain to-be-identified voice data; extracting a target vocal print characteristic corresponding to the to-be-identified voice data to acquire a standardvocal print characteristic corresponding to the account number identifier; carrying out similarity calculation on the target vocal print characteristic and the standard vocal print characteristic toobtain a first matched result; converting the target vocal print characteristic into target character data and carrying out similarity calculation on the target character data and the target random code to obtain a second matched result; and acquiring an unlocking command based on the first and second matched results to control the intelligent lock to be unlocked. The problem that the intelligentlock is not good in safety is solved.