A multi-channel medical waste pretreatment machine with a needle shearing function includes a disposable infusion plastic bottle treatment channel, an infectious waste treatment channel, a damage waste treatment channel, a control system and an integral cabinet. The disposable infusion plastic bottle treatment channel includes a smart induction feeding port, a demolition box with a needle shearingfunction, a weighing sensor, an ultraviolet and ozone disinfection lamp, a blanking pipe, a scanner and a medical waste special bag. The infectious waste treatment channel includes a smart inductionfeeding port, a weighing sensor, an ultraviolet and ozone disinfection lamp, a scanner and a medical waste special bag. The damage waste treatment channel includes a damage waste feeding port formed in the surface of the integral cabinet, an upper chute, a second driven gear, a cover plate, a bottom plate, a lower chute, a sharps box, a weighing sensor and a scanner. Finally, a generation department, waste category, generation time, weight information and an outer package process label of each bag (box) of waste are associated to achieve informationization of the medical waste source.