The invention relates to a method and device for clearing a DC line fault of a hybrid multi-terminal DC transmission system. For a DC system composed of a rectifier station and N-1 inverter stations (N is greater than or equal to 3), there are N-2 busbar areas on a DC line for connecting the rectifier station on the head end and the inverter station on the tail end, each busbar area is connected with an intermediate inverter station, when the DC line between two adjacent busbar areas or the DC line between the busbar area on the tail end and the inverter station on the tail end is faulty, theDC system is controlled to be restarted; and if the DC system is restarted unsuccessfully, the inverter station at the downstream of the faulty DC line is locked, and the intermediate inverter stationand the rectifier station on the head end on the upstream of the faulty DC line are restarted. By adoption of the method and device provided by the invention, the power loss during the line fault andthe disturbance to an AC system are reduced, and the fault clearing of the line fault of the hybrid multi-terminal DC transmission system is realized through a specific line fault clearing method, sothat the reliability of the hybrid multi-terminal DC transmission system is improved.