A method and system for centralized management and control of data security are provided in that embodiment of the present invention, in accordance with that present invention, the method is applied to a data security centralized management and control system, The data security centralized management and control system is connected with at least one security management and control system. The method comprises the following steps: selecting specific data from data assets as target data and sensing to obtain the data security status of the target data, wherein, the target data is selected according to the data security protection requirements; Analyzing and evaluating the data security state to generate an analysis and evaluation result; At least one security management and control system access to that target data is triggered to perform security management and control on the target data accord to the specific policy matched according to the analysis and evaluation result. The embodiment of the invention not only supports the protection when and after the attack and malicious behavior occurs, but also can predict and alert before the attack and malicious behavior occurs.