The invention provides a guide seal structure and an arc extinguishing chamber and a circuit breaker using the structure, The guide seal structure comprises a compressor cylinder and a piston barrel,wherein the compressor cylinder and the piston barrel are gap-fitted and a guide ring is arranged between the compressor cylinder and the piston barrel, a mounting groove for mounting the guide ring is arranged in the compressor cylinder or the piston barrel, and a communication channel for communicating the mounting groove and the compression chamber is also arranged on the compressor cylinder orthe piston barrel. When the brake is switched off, the compressor cylinder is far away from the static contact, the gas in the compressor chamber is compressed, and the gas pressure is increased. Under the action of the internal and external pressure difference, the high-pressure gas in the compressor chamber enters the installation groove through the communication channel, pushes the guide ringto expand and move outward, and contacts with the inner wall of the piston barrel or the inner wall of the compressor cylinder, so as to realize the sealing and guiding function. When the cylinder isclosed, the volume of the compression chamber becomes larger and negative pressure is generated when the cylinder is close to the static contact. Under the action of the internal and external pressuredifference, the guide ring clings to the bottom of the mounting groove, so that a certain movement gap is maintained between the cylinder and the piston barrel, so that the closing resistance is notincreased and the piston barrel plays a good guiding role.