The invention belongs to the technical field of sandstone-type uranium mine mineralization prediction, and relates to a sandstone-type uranium mine favorable mineralization lithofacies belt positioning method. The method includes the following steps that: step 1, regional geological data are collected, and a sandstone-type uranium mine uranium-prospecting key area and target horizon are determined; step 2, the sedimentary facies type and spatial distribution characteristics of the key area and the target horizon in the step 1 are sorted; and step 3, the sedimentary facies belt of favorable uranium mineralization is delineated qualitatively and quantitatively on the basis of a uranium-bearing stratum structure, sand body physical properties, lithological combinations, paleoclimate, oxidizing zone developmental conditions and uranium-bearing geological conditions.