The invention discloses a printing machine with a multi-set color combination function. The printing machine comprises a printing machine shell, a printing paper roller rack is fixedly connected to the side face of the printing machine shell, and a printing paper rotation shaft is fixedly connected to the surface of the printing paper roller rack through a bearing; a printing paper roller is fixedly connected to the surface of the printing paper rotation shaft, a paper inlet is formed in the side face of the printing machine shell, and a first transmission supporting rod is fixedly connected to the bottom of an inner cavity of the printing machine shell; a first transmission rotation shaft is fixedly connected to the surface of the first transmission supporting rod through a bearing, and afirst transmission roller is fixedly connected to the surface of the first transmission rotation shaft. According to the printing machine with the multi-set color combination function, through smallink boxes, a piston block, a piston rod, a transparent observation plate and a pull ring, when multiple sets of colors of ink need to be mixed, the piston block can be pressed through the pull ring, twelve kinds of ink different in color are conveyed to the combination ink boxes for combination according to demands, and the effect of more color combinations of the printing machine is achieved.