The invention belongs to the field of pharmaceutical preparations, in particular to a lyotropic liquid crystal drug carrier and a preparation method and application thereof. Twain-80, soybean lecithin, ethyl oleate and water in a certain proportion can obtain lyotropic liquid crystal phase, further adjusting that proportion of reagent, and confirm that hexagonal phase lyotropic liquid crystal andlamellar phase lyotropic liquid crystal are also prepared by polarizing texture measurement. It is found that the hexagonal and layered phases have good shear viscosity, which means that the crystalline phase has good stability and can be used as drug carrier. Curcumin is encapsulated in hexagonal phase and drug release is investigated. The results showed that hexagonal phase had good sustained-release effect and the release curve of layered phase fitted the first-order kinetic equation well. The suitable release dosage form could be selected according to the clinical application.