The invention provides a sealing and flushing teaching simulation device with detection function, the invention is used for solving the technique of pulse flushing and sealing and positive pressure sealing in the prior art, students are unable to practice operational learning, The sealing and flushing teaching simulation device with detection function comprises: a model base, a sealing tube model,a retaining needle assembly and a detecting module. The sealing tube model is embedded into the model base.The sealing model comprises a transparent tube body and a simulated human skin arranged on the transparent tube body, wherein the simulated human skin is provided with a preset insertion hole; the sealing model is inserted into the simulated human skin through the preset insertion hole; andthe preset insertion hole is connected with the detection module. The teaching simulation device can not only simulate the action of irrigation and sealing, but also detect whether the steps of irrigation and sealing meet the requirements, effectively improve the rate of clinical nursing irrigation and sealing technology, improve the safety of clinical infusion treatment and patient satisfaction,and further reduce the medical cost of patients.