The present invention relates to a method for changing the intercellular mobility of an m RNA of a gene in an organism, comprising: modifying a t RNA-like structure present in the m RNA by mutating the gene from which the m RNA is transcribed, or including the sequence of a t RNA-like structure in the transcribed part of the gene. The method is in particular suited for plants. The intercellular mobility can be between different organs. Mutating the gene is for example for inducing loss of mobility of the transcript and comprises deleting the sequence of the tRNA-like structure from the gene, mutating the sequence of the t RNA-like structure to change the tridimensional configuration thereof, or inserting a genetic element into the gene to remove the tRNA-like structure from the transcribedpart of the gene, or for inducing a change in the destination of the transcript and comprises modifying the sequence of the t RNA-like structure from the gene such that the transcript is addressed toa location different from the original destination of the transcript.