The invention discloses a protection setting and key safety measures checking method based on a 61850 client, which sequentially carries out the following steps: comparing three EXCEL format setting sheets to check whether the setting and the soft pressure plate in the three setting sheets are consistent; monitoring the overhaul state of the protection device to be overhauled and monitoring the alarm signal of GOOSE overhaul inconsistency of the protection device to be overhauled, and realizing the recognition of the overhaul state of the protection device to be overhauled and its related devices through the monitored state quantity; reading the overhaul status of the protection device to be overhauled in real time, the soft platen state and the GOOSE link communication state, to realizethe alarm function of whether the secondary security measures are missing, The protection setting and key safety measures checking method based on 61850 client is provided. When it is applied, it canmake the setting of protection device, check of soft pressure plate fully automatic, and real-time monitor and alarm some key safety measures which may lead to power network safety accidents in the process of maintenance.