The invention relates to the technical field of adhesive, and in particular to a low temperature-resistant pressure-sensitive adhesive and a preparation method thereof. The low temperature-resistant pressure-sensitive adhesive is mainly prepared from the following material components in parts by weight: 7 to 35 parts of isocyanate monomer and polyether polyol, 30 to 70 parts of acrylic ester monomer, 1 to 5 parts of hydroxyacrylic acid monomer, 5 to 50 parts of reactive tackifying resin, 0.1 to 1 part of initiator, 0.1 to 1 part of curing agent and 70 to 130 parts of ethyl acetate. Compared with the prior art, labels prepared from the pressure-sensitive adhesive disclosed by the invention can be used for a long time under a negative 80 DEG C low-temperature environment, and even can be used in a negative 196 DEG C liquid nitrogen environment, and cannot come off, warp or deform.