The invention discloses a composition capable of reducing alcohol drinking response and reducing alcoholic liver injuries and application. The composition is prepared from the following raw material:a broad-spectrum composite digestive enzyme, milk thistle, N-acetylcysteine, an antioxidant and activated multivitamin B, wherein the broad-spectrum composite digestive enzyme comprises disaccharidase, amylase, cellulase, lipase, a proteolytic enzyme and the like; the activated multivitamin B comprises B1, activated B2, B3, B5, activated B6, activated B9, B7 and activated B12. Meanwhile, the invention also discloses the application of the composition capable of reducing the alcohol drinking response and reducing the alcoholic liver injuries to an alcohol effect dispelling preparation. The formula disclosed by the invention is a functional nutrient with pertinence and is used in sequence according to a certain combination; the composition is convenient and feasible and can have good effectsof reducing the alcohol drinking response and reducing the alcoholic liver injuries; the alcohol effect dispelling effective rate of the composition can be not less than 80 percent.