The invention discloses scutellarin toothpaste. The scutellarin toothpaste is prepared from the following components: scutellarin, polyphyllin I, a codnopsis bulleyana forrest ex diels water extract,a functional additive and other additives, wherein the mass ratio of the scutellarin to the polyphyllin I to the codnopsis bulleyana forrest ex diels water extract is 6 : 4 : 3, and the concentrationof the codnopsis bulleyana forrest ex diels water extract is 0.2g/mL. The scutellarin is used for treating and preventing periodontitis and protecting the integrity of parodontium; the living environment and survival of periodontal ligament stem cells are improved, the proliferation capacity of the periodontal ligament stem cells is enhanced, and the osteogenic differentiation of the periodontal ligament stem cells is promoted. The scutellarin toothpaste has a good effect.