The invention provides a state estimation calculation method based on special CPU + GPU hybrid structure, comprising the following steps: step 1, splitting a large power network according to a weak connection distribution; step 2, calculating a state estimation method based on mixed isomerism of CPU and GPU. 2, according to the scale of the power network, determine the proportion of the mixed computing architecture; 3, dividing the Jacobian matrix of a single node in the subnet into blocks accord to the computing capability of the parallel computing architecture; 4, distributing the resourcesof the pow grid parameters by a hybrid parallel architecture; 5, after the operation of each subnet is finished, calculate the state quantity of the node directly connected with the weak connecting line; Each subnet takes the external state quantity of the boundary node as the parameter, transforms the subnet into the external transparent node, simplifies the large power network into a small network with each subnet as the node and weak connection as the tie line, and then estimates the state of the whole network. Using a CPU + GPU hybrid computing architecture in floating-point computing such as outstanding performance, according to different networks, combined with different proportions of hybrid computing architecture, to achieve higher computing speed.