The invention discloses a graphene reinforced titanium-based composite material characterized by three-dimensional network-shaped distribution, a preparation method of the graphene reinforced titanium-based composite material and application of the graphene reinforced titanium-based composite material. The graphene reinforced titanium-based composite material is mainly characterized in that titanium or titanium alloy serves as a titanium base, graphene serves as the reinforced phase, and the graphene is uniformly distributed around titanium base particles to form a three-dimensional network-shaped structure in the microstructure of the composite material, namely, the graphene reinforced titanium-based composite material is similar to a graphene reinforced titanium-based composite materialwhich is formed in the mode that the titanium base particles are placed in meshes of the graphene three-dimensional network-shaped structure in a filled mode and are completely compact. According to the graphene reinforced titanium-based composite material, a method of a cross-linking reaction is adopted, and therefore the graphene well covers the surfaces of the titanium base particles, the problems that by the adoption of a conventional ball milling method, impurities are prone to being guided into materials, and uniform covering of the graphene is difficult to achieve are solved, and a graphene reinforced titanium-based composite material block characterized by three-dimensional network-shaped distribution is obtained through sintering molding. The graphene reinforced titanium-based composite material has the high strength, the high plasticity and the excellent comprehensive mechanical properties, and can be applied to the fields of national defense military industries, such as theaerospace field and the ship and naval vessel field.