The invention relates to a wetting-resisting super-hydrophobic membrane and a preparation method thereof. Combined nanoparticles are coated with a low surface energy solution to form a rough structure, and a PDMS-SiO2-PDMS sandwich compound layer is formed on the surface of the membrane. The compound layer has the advantages of rough structure and low surface energy, the membrane has super hydrophobicity, and the membrane further has high wetting resistance in a membrane distilling process. The membrane can be utilized to perform direct contact type membrane distillation to treat a water bodycontaining a surface active agent, so that membrane distillation operation time is obviously prolonged, stable operation time is 20 times or more of that of a PVDF original membrane, and water production capacity can be improved by 15 times or more.