The invention discloses a guide wire pushing device. The device comprises a shell, a main pushing wheel and an auxiliary pushing wheel, wherein the shell is provided with a guide wire inlet and a guide wire outlet; both the main push wheel and the auxiliary push wheel are rotatably arranged in the shell; in which at least a part of the rim of the main push wheel is arranged opposite to at least apart of the rim of the auxiliary push wheel to form a clamping space for clamping the guide wire between at least a part of the rim of the main push wheel and at least a part of the rim of the auxiliary push wheel, the guide wire is penetrated into the shell from the inlet of the guide wire and is penetrated through the clamping space from outlet of the guide wire, when the main pushing wheel rotates, the main pushing wheel is matched with the auxiliary pushing wheel to clamp the guide wire to move along the direction from the guide wire inlet to the guide wire outlet, so that the guide wire can be automatically pushed into the human body during the gastroscopic operation, which is fast, convenient, time-saving and labor-saving, moreover, the device solves the time-consuming and laboriousproblem of adopting the manual mode to push the guide wire into the human body when performing gastroscopic operation in the prior art.