The invention discloses a hybrid line distance protection setting calculation method. The method comprises the following steps of: acquiring a protection range of a distance protection section I and adistance protection section II; Calculating a distance protection impedance setting value of the distance protection section I and the distance protection section II according to the end positions ofthe protection ranges of the distance protection section I and the distance protection section II and the mixed line parameters; Determining, according to the distance protection impedance setting value, hybrid line parameters and operating characteristic boundary angles, the operating characteristics of the distance protection in the distance protection section I and the distance protection section II; The hybrid line includes the first overhead section, the GIL section and the second overhead section. The embodiment of the invention accurately calculates the distance protection setting value of the GIL-overhead hybrid line according to the electrical parameters of the GIL-overhead hybrid line and the required protection range, so that the distance protection can be used as a safe and effective backup protection for the GIL-overhead hybrid line and important practical value is realized.