The invention discloses an organic glass protective cover. The organic glass protective cover structurally comprises a positioning shaft, a positioning sleeve, an adjusting knob, a control device anda protective cover. The positioning shaft is of a cylindrical structure, and the left end of the positioning shaft is overlapped with the upper end of the positioning sleeve in a sleeving mode, the adjusting knob is arranged at the top of the positioning sleeve, and the tail end of the control device is installed at the right end of the positioning shaft in a fastening mode. According to the organic glass protective cover, the control device performs control through an adjusting mechanism when the protective cover needs to be fixed to enable a negative pressure generating mechanism to generatea vacuum negative pressure value, and then negative pressure guide mechanisms are separately connected to adsorption mechanisms to perform adsorption and fixing to fix the protective cover; and a dust removing device can carry out dust removing on the surface of the protective cover through cleaning cotton in the adjusting and moving process of the protective cover, when the organic glass protective cover is integrally used, the automatic cleaning function is achieved, and the protective cover can be positioned at any angle, so that the convenience of using is greatly improved.