A 120-first aid informatization system comprises an application layer, a platform layer, a network layer, and a terminal layer, wherein the application layer comprises an intelligent scheduling module, an electronic medical record module, a green channel module, a navigation module and an implementation supervision module, the platform layer comprises a first-aid medical information service module, a remote medical information service module and a regional medical information service module, and the terminal layer is a client terminal equipment module. A 4G network, an internet of things and other communication technologies are comprehensively utilized, and mobile communication monitoring is deployed on a first-aid vehicle, so that the functions of vital sign monitoring, data sharing, remote consultation and the like are achieved. A quantitative model research and development method is adopted, and different modules are designed, developed and integrally tested as independent subsystems in an incremental model, and can be independently modified according to different applications and requirements without affecting the development of the system architecture and other subsystems.