The invention discloses a manufacturing method of non-woven cloth for wet tissue. A manufacturing device comprises a first carding machine, a second carding machine, a cotton presser, a spunlacing machine, a dryer and a winding machine, wherein the first carding machine processes a first cotton material into a first cotton web, the second carding machine processes a second cotton material into a second cotton web, the first cotton web and the second cotton web are pressed thinly through the cotton presser, a blended fiber web passes through the spunlacing machine, then is dried through the dryer and wound into multifunctional special non-woven cloth for super-cotton-like wet tissue through the winding machine. The manufacturing method of the non-woven cloth for the wet tissue has the advantages that absorbent cotton or viscose and a super-cotton-like fiber are mixed and carded into a web, the web is laid, through the spunlacing machine, novel composite non-woven cloth is manufactured,not only are the natural properties of softness and comfort kept, but also the cost is reduced, the fiber is formed through 'continuous copolymerization, profiled spinning and printing and dyeing treatment', and in addition to good moisture absorption and rapid drying, the fiber further has softness, ultraviolet resistance, antistatic performance and fluffiness.