The invention discloses a multi-objective optimization operation method for a combined cooling, heating and power supply system, which comprises the steps of firstly establishing mathematical models respectively for equipment of a combined supply system and a separated supply system; then respectively calculating the total operation cost, the total carbon emission and the total primary energy consumption of the combined supply system and the separated supply system in allusion to each set of the equipment; building a multi-objective optimization model by adopting a weighting method, then performing single-objective optimization solving on the separated power supply by adopting a mixed integer linear programming solver, finally obtaining an optimization operation strategy of the combined supply system, and being coupled to a ground source heat pump. The multi-objective optimization operation method can effectively improve the energy utilization efficiency of terminal users, alleviate the contraction between energy supply and demand in a regional power grid, promote the local absorption of distributed renewable energy and realize social benefits of the combined supply system to the greatest extent.