The invention discloses a large double-color injection molding system. The system comprises a screw rod extrusion feeding device, a pigment filling device, a material storage tank, an injection nozzle, an injection guide rail, a glue injection head plate, a glue injection tail plate, a base and a mold locking structure, the screw rod extrusion feeding device is vertically connected with the pigment filling device, the material storage tank is connected with the pigment filling device and injection nozzle through material storage pipe flanges, a shuttle valve is arranged in each material storage pipe flange, the injection guide rail is fixedly arranged on the base, the mold locking structure comprises a bearing base, a fixed mold fixing plate, a movable mold fixing plate, a top plate, a mold locking guide rail and a mold locking oil cylinder, pressure sensors are arranged inside the injection nozzle and outside the mold locking oil cylinder, and the pressure sensors communicates with acontroller. The system has the advantages that structure is simple, energy is saved, operation is convenient, occupied area is small, the injection molding force and the mold locking force can be accurately controlled, the mold can be protected, and the quality of a molding piece can be ensured.