The invention discloses a production method of a liquid-cooling cable. The production method comprises the following steps that a liquid-cooling pipe and a plurality of conductor core lines penetratethrough a corresponding pipe hole and line holes of a twisting disc, the liquid-cooling pipe and the plurality of conductor core lines which penetrate through the twisting disc penetrate through an eye die, the liquid-cooling pipe and the plurality of conductor core lines are output through the eye die and are contracted to form a liquid-cooling conductor with a certain diameter after twisting ofthe twisting disc; and the liquid-cooling conductor is insulated, extruded and coated to form an insulation layer. The production method is simple and is high in production efficiency.