The invention discloses a novel indolopyridone drug molecule as well as a preparation method and application thereof and belongs to the technical field of pharmaceutical synthesis. According to the technical scheme provided by the invention, the novel indolopyridone drug molecule has a structural formula shown as follows: the formula is shown in the description, wherein R is p-fluorobenzene, quinoline and indole. The invention further provides a preparation method of an indolopyridone type compound with anti-tumor activity. The novel indolopyridone drug molecule prepared by the invention has relatively good inhibition activity on a breast cancer cell MCF-7 and has a potential of being prepared into an anti-tumor drug.