The invention discloses a precast prestressed fabricated beam and column joint. The precast prestressed fabricated beam and column joint is characterized in that the precast prestressed fabricated beam and column joint comprises precast concrete columns (1), precast concrete beams (2) and a beam and column joint post-pouring area (3); the precast concrete columns (1) are arranged at the upper endand the lower end of the beam and column joint post-pouring area (3) correspondingly, and the precast concrete beams (2) are arranged at the left end and the right end of the beam and column joint post-pouring area (3) correspondingly; prestressed beams serve as the precast concrete beams (2); and prestressed tendons (7) are arranged in the precast concrete beams (2) and cut off in the beam and column joint post-pouring area (3). By adopting the precast prestressed fabricated beam and column joint, the anti-seismic effect of the beam and column joint can be improved.