The invention provides a manufacturing method for a car steering wheel cover capable of relieving fatigue driving. The manufacturing method comprises the steps of 1, preparing a primer, wherein the primer comprises, by mass, 20-30% of water, 30-40% of polyurethane resin, 15-20% of acrylic resin, 10-15% of delustering filler, 5-15% hand-feeling wax and 10-15% pigment paste; 2, smearing the primer on the surface of a leather; 3, preparing a rolling paint, wherein the rolling paint comprises, by mass, 25-30% of water, 30-40% of polyurethane resin, 5-15% of acrylic resin, 10-20% of color-changingpowder and 10-15% of adhesion agent; 4, conducting rolling coating of the rolling paint on the surface of the leather; 5, preparing a spraying paint, wherein the spraying paint comprises, by mass, 45-50% of polyurethane resin, 45-50% of water, 2-5% of hand-feeling addition agent and 2-5% of cross-linking agent; 6, spraying the spraying paint on the surface of the leather; and 7, manufacturing theleather into the steering wheel cover. In the running process of a car, the car steering wheel cover capable of relieving fatigue driving can change colors automatically when a certain temperature isreached, and thus visual impact is brought about; fatigue driving can be relieved; and occurrence of traffic accidents is reduced.