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CN108753960A 一种胃癌预后分子标志物非编码RNA Lnc-DENR-2及其应用 无效 - 撤回

一种胃癌预后分子标志物非编码RNA Lnc-DENR-2及其应用
摘要：
本发明涉及胃癌预后分子标志物非编码RNA Lnc‑DENR‑2及其应用，可有效解决制备预测胃癌患者预后的试剂盒的问题，一种胃癌预后分子标志物非编码RNA Lnc‑DENR‑2，其转录本长度大于200个核苷酸，序列为SEQ NO:1，在制备胃癌预后实时荧光定量PCR检测试剂盒中的应用，该试剂盒包括置于盒体内的用于检测胃癌患者预后的试剂盒表达的特异性引物，引物序列为SEQ No：2和3、内参基因TUBA1A表达的引物序列，引物序列为SEQ No：4、5和从胃组织中提取RNA，并进行逆转录及荧光定量PCR的试剂，本发明非编码RNA Lnc‑DENR‑2作为胃癌预后新的分子标志物，可及时预测胃癌预后，并及时对胃癌患者进行治疗，延长患者生存时间，提高生存率，是胃癌预后上的一大创新。
摘要（英）：

The invention relates to non-coding RNA Lnc-DENR-2 for a gastric cancer prognosis molecular marker and application thereof, and can effectively solve the problem of preparing a kit for predicting prognosis of gastric cancer patients; a transcript of the non-coding RNA Lnc-DENR-2 for the gastric cancer prognosis molecular marker is greater than 200 nucleotides in length, the sequence is SEQ NO: 1,and the application is use of the non-coding RNA Lnc-DENR-2 in the preparation of a real-time fluorescent quantitation PCR detection kit for gastric cancer prognosis. The kit includes specific primers, primer sequences expressed by internal reference gene TUBA1A, RNA extracted from gastric tissues, and a regent for reverse transcription and fluorescence quantification, the non-coding RNA Lnc-DENR-2 as a new gastric cancer prognosis molecular marker can predict the gastric cancer prognosis in time, timely treats the gastric cancer patients, prolongs the survival time of the patients, improves the survival rate, and is an innovation for the gastric cancer prognosis.

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