The invention discloses a centrifugal positioning type mixing device. The device comprises a barrel, motors, a centrifugal device and a shear device, wherein the centrifugal device and the shear device are both mounted in the barrel. A centrifugal nut on the lower side of a centrifugal block and the centrifugal block are in matched insertion positioning through positioning teeth and positioning grooves, so that the centrifugal block is firmly positioned by the clamping force of the centrifugal nut and transversely positioned by the positioning teeth, and the centrifugal block is firmer after receiving external impact force.