The invention discloses a puncture-resistant vibration reduction shoe, which comprises a shoe body, wherein the front end of the shoe body is provided with a protection vamp; a protection metal sheetis embedded and connected in the protection vamp; an elastic protection pad is arranged at the bottom of the shoe body, and comprises a first elastic pad layer and a second elastic pad layer in vertical opposite arrangement; a first plastic pad layer is arranged at the bottom of the first elastic pad layer; a second plastic pad layer is arranged on the top of the second elastic pad layer; a plurality of springs are uniformly distributed between the first plastic pad layer and the second plastic pad layer; a plurality of parallel grooves are formed in the bottom of the first elastic pad layer;correspondingly, a plurality of parallel grooves are formed in the top of the second elastic pad layer; a hollow gasket is arranged in each groove; non-Newtonian fluid is filled inside the hollow gasket. The puncture-resistant vibration reduction shoe has a good puncture-resistant effect and good elastic buffer effects; the good dealing can be performed on sudden stress.