The invention provides a 100,000 volt DC high voltage generating device consisting of a medium voltage generating device and a high voltage generating device, wherein the medium voltage generating device comprises a medium voltage magnetic port, a medium voltage coil skeleton, medium voltage coil primary and secondary windings and a PCB, the high voltage generating device comprises a high voltagemagnetic port, a high voltage coil skeleton, high voltage coil primary and secondary windings, high-frequency transmitting electronic tubes, a high-voltage cable, a high-voltage silicon rectifier stack and a high-voltage capacitor, and both of the medium voltage generating device and the high voltage generating device are packaged in a space enclosed by a bottom plate, a base frame, a middle frame, an upper frame and a protection net cover; the medium voltage generating device is controlled by an ARM chip and a VMOS power tube on the PCB, and the high voltage generating device is controlled bya pair of high-frequency transmitting electronic tubes constituting a push-pull circuit, in order to prevent high-voltage flicker and creepage, the device is packaged by epoxy resin after being assembled, and as the topological structure of the power circuit adopts a hybrid VMOS and the high-frequency transmitting electronic tube, the 100,000 volt DC high voltage generating device is widely usedin high-voltage electrostatic dust removal, spraying, seed selection and electrostatic spraying equipment.