The invention belongs to the field of machining methods of spiral sleeves and discloses a machining method for an asymmetric structure/nonlinear variation spiral groove. The machining method comprisesthe steps that rough machining is conducted, the radial compensation quantity dX and the axial compensation quantity dZ are adjusted along a spiral sleeve matched curved face, and subsequent fine cutting machining and the like are conducted. Through the machining method, the asymmetric structure/nonlinear variation spiral groove can be machined, and the flange molded line and characteristic curveof the asymmetric structure/nonlinear variation spiral groove can be machined in a highly matched mode.